Predictive factors associated with survival rate of cervical cancer patients in Brunei Darussalam

Abstract

Introduction: Cervical cancer is the third most prevalent cancer among women in Bru-nei Darussalam. This study aims to report the overall survival rates and associated factors of pa-tients diagnosed with malignant cervical cancer in Brunei Darussalam. Methods: A retrospective study of patients diagnosed with cervical cancer from 2007 to 2017 in Brunei Darussalam. The data were obtained from the population-based cancer registry in Brunei Darussalam. Kaplan-Meier survival analysis was used to estimate the overall survival rates at 1-, 3- and 5-year inter-vals while the log-rank test was used to assess differences in survival between groups. Cox Pro-portional Hazard (PH) regression analysis was used to examine the association of demographic and clinical factors on the survival of cervical cancer patients. Results: A total of 329 registered malignant cervical cancer cases were analyzed. The mean age at diagnosis of patients with cervi-cal cancer was 46.7 ± 12.2 years. There were 28.6% deaths and the overall survival rates at 1, 3 and 5 years were 85.4%, 72.6% and 68.6% respectively. Age at diagnosis, cancer stage and his-tology types were significant predictive factors for overall survival of the patients diagnosed with cervical cancers when analysed on both log rank tests and Cox PH model. Conclusion: Age at di-agnosis, cancer stage and histology types were significantly associated with the overall survival rates of cervical cancer patients in Brunei Darussalam. Early detection and management of cervi-cal cancer at early stages should be prioritized to improve the survival rate and quality of cancer care.

Publication
Brunei International Medical Journal